How Does Cancer Treatment Affect Immune Health in HIV Patients?

In people with HIV and cancer, antiretroviral therapy is often used during cancer treatment to mitigate complications of HIV progression. However, questions regarding long-term effects of cancer treatment in this patient population remain, such as the immunosuppressive effects on HIV RNA level and CD4 count, which are indicators of a patient's morbidity and mortality. Therefore, scientists sought to measure the link between these biomarkers and associated mortality after cancer treatment. They p...

Osimertinib for EGFR-Mutated Advanced NSCLC: An Interview with Suresh S. Ramalingam, MD

The treatment of advanced-stage non-small cell lung cancer (NSCLC) has improved steadily in the past few years, and individualized therapy for patients with mutations in the epidermal growth factor receptor (EGFR) is applied in routine clinical practice. While EGFR-mutated NSCLC is effectively treated with tyrosine kinase inhibitors (TKIs) such as erlotinib or gefitinib, there is a need to develop more effective treatments to improve outcomes in these patients. In a study now published in The Ne...

MRI Reduces Interval Breast Cancers in Dense Breasts

A randomized clinical trial reports that for women with extremely dense breasts, supplemental screening with magnetic resonance imaging (MRI) can reduce the incidence of interval breast cancers¬≠¬≠, those detected within 12 months of a mammography in which findings are considered normal. Extremely dense breast tissue increases the risk of breast cancer, but it also increases the chances that cancer will be missed on a mammogram. While federal law requires the reporting of breast density in ma...

Dasatinib Improves Outcomes in Patients With Chronic Myeloid Leukemia and High BMI

According to a subgroup analysis of a phase 3 study, dasatinib produces significantly faster and more durable responses compared with imatinib in patients with chronic phase chronic myeloid leukemia (CML) and a high body mass index (BMI). Previous studies have reported that patients with a high BMI, defined as over 25 kg/m 2 , are at an increased risk of not only developing CML but also of experiencing poorer outcomes when treated with first-line tyrosine kinase inhibitors (TKIs) such as imatini...

Prescribing a Healthy Diet and Exercise for Breast Cancer With Neil Iyengar, MD

Patients with breast cancer can derive significant benefits from eating well and staying physically active during their treatment. In his previous interview with i3 Health, Neil Iyengar, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center, explained the roles that nutrition and exercise can play in the prevention and treatment of breast cancer. In this second installment, Dr. Iyengar discusses the personalized strategies that are most likely to benefit patients. In addition, he of...

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