Prostate Cancer: CHIP Interferes With PARP Inhibitor Eligibility Testing

In a case series study in advanced prostate cancer, 10% of patients were shown to have clonal hematopoiesis of indeterminate potential (CHIP) variants in genes used to determine eligibility for poly(ADP)-ribose polymerase (PARP) inhibitor therapy, making it essential that circulating free DNA (cfDNA) testing include a paired whole-blood control to exclude CHIP variants and avoid misdiagnosis. "There is an urgent need to better understand this problem following recent US Food and Drug Admini...
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CTC Count-Driven Treatment Improves Survival in HR-Positive, HER2-Negative Metastatic Breast Cancer

Using circulating tumor cell (CTC) count to determine whether chemotherapy or endocrine therapy is used improves survival outcomes compared with clinically determined treatment in patients with hormone receptor (HR)-positive, HER2-negative metastatic breast cancer, according to the results of the open-label, randomized phase 3 STIC CTC trial published today in JAMA Oncology. The investigators, led by François-Clément Bidard, MD, PhD, Professor of Medicine at the University of Paris-Sac...
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Transoral Robotic Surgery Improves Survival in Older Patients With HPV-Related Oropharyngeal Carcinoma

Transoral robotic surgery with pathologic characteristics-guided adjuvant therapy may improve survival outcomes in older patients with human papillomavirus (HPV)-related oropharyngeal carcinoma (OPSCC), according to a retrospective cohort analysis now published in JAMA Otolaryngology–Head & Neck Surgery. Because patients over 70 years of age are underrepresented in clinical trials for HPV-related oropharyngeal cancers, the optimal way to treat these patients remains controversial. Additional...
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For Patients With Metastatic Colorectal Cancer, Diet Does Not Improve Survival

Diet quality did not improve overall survival in patients with metastatic colorectal cancer (mCRC), according to a prospective cohort study published today in JAMA Network Open. The investigators, led by Erin Van Blarigan, Scd, Assistant Professor of Epidemiology & Biostatistics and of Urology at the University of California, San Francisco, evaluated the diet qualities of 1,284 patients with metastatic colorectal cancer from October 2005 to February 2012. The patients were enrolled into Canc...
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Liver Cancer: Delayed Diagnosis, Increased Mortality in Rural and Low-Income Households

Patients living in low income or rural communities have less access to care for liver disease, leading to worse outcomes and advanced tumor stage at diagnosis for hepatocellular carcinoma (HCC), according to the results of a retrospective analysis now published in the journal Cancer. The investigators, led by first author Robert Wong, MD, of the Department of Gastroenterology and Hepatology at the Veterans Affairs Palo Alto Healthcare System and the Stanford University School of Medicine in Palo...
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