Breast Cancer and COVID-19: Treatment, Triage, and Prioritization

The American Society of Breast Surgeons has released an executive summary of recommendations for prioritizing, treating, and triaging patients with breast cancer during the COVID-19 pandemic."The COVID-19 pandemic poses unprecedented challenges for patients, clinicians and health care systems," write the authors, led by Jill R. Dietz, MD, FACS, President of the American Society of Breast Surgeons. Written by representatives from multiple cancer care organizations with expertise in the multidisci...
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Expanding Later-Line Treatment Options for Multiple Myeloma: Paul G. Richardson, MD

Earlier this month, ​the FDA approved isatuximab-irfc (Sarclisa​®​, Sanofi), an anti-CD38 monoclonal antibody, in combination with pomalidomide and dexamethasone for adults with multiple myeloma who have received at least two prior lines of treatment, including lenalidomide and a proteasome inhibitor. In this interview with i3 Health, Paul G. Richardson, MD, who served as the co-primary investigator of the ICARIA-MM study, on which the isatuximab approval was based, shares his thoughts on the si...
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Increased COVID-19 Risk in Patients With Cancer

Patients with cancer are at increased risk of infection with severe adult respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, according to a medical records review of patients with cancer at a hospital in Wuhan, China."Patients with cancer from the epicenter of a viral epidemic harbored a higher risk of SARS-CoV-2 infection… compared with the community. However, fewer than half of these infected patients were undergoing active treatment for their cancers," note the investigat...
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Head and Neck Cancer: What Factors Affect Risk of In-Hospital Mortality?

​Along with a variety of other patient- and hospital-related factors, male sex, weekend admissions, and treatment at nonteaching hospitals are associated with increased in-hospital mortality for patients with head and neck cancer, report the authors of a cross-sectional study published today in JAMA Otolaryngology—Head and Neck Surgery.Using the 2008 to 2013 National Inpatient Sample database, the investigators identified adult hospitalized patients diagnosed with either primary or secondary hea...
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Breast Cancer: BRCA1/2 Mutations Enhance Chemotherapy’s Efficacy

Carriers of germline variants in the BRCA1 and BRCA2 genes are more likely to experience a pathologic complete response to two different chemotherapy regimens, according to a retrospective study now published in JAMA Oncology.This study was a secondary analysis of data from the GeparOcto multicenter prospective clinical trial, in which 945 women with different subtypes of high-risk, early-stage breast cancer were randomized to receive either sequential intense dose-dense epirubicin/paclitaxel/cy...
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