In recent years, a number of lawsuits have highlighted concerns regarding a possible link between ovarian cancer risk and the use of talc-containing cosmetic powders in the genital area. However, a large pooled analysis now published in JAMA reports no statistically significant association between genital powder use and ovarian cancer.The potential connection between genital powder use and ovarian cancer risk was first investigated because of the relationship between talcum powder and asbestos,...
A phase 3 trial reports that olaparib as maintenance therapy in combination with bevacizumab increases progression-free survival (PFS) in patients with newly diagnosed, advanced high-grade ovarian cancer both with and without BRCA mutations.While previous studies have found that maintenance olaparib is associated with improved outcomes in patients with ovarian cancer with BRCA mutations, its efficacy in patients without BRCA mutations had not been confirmed. In the phase 3 PAOLA-1 trial, a team ...
The FDA has approved niraparib (Zejula®, Tesaro, Inc.) for patients with advanced ovarian, fallopian tube, or primary peritoneal cancer who experience disease progression following three or more lines of chemotherapy. Niraparib is indicated for patients whose tumors are positive for homologous recombination deficiency (HRD).The approval was based on QUADRA (NCT02354586), a multicenter, open-label, single-arm, phase 2 trial that enrolled 463 patients with relapsed, high-grade serous epithelial ov...
Pre-activity assessment data from i3 Health's continuing medical education (CME)/continuing nursing education (CNE) activity "Optimizing the Management of Advanced Cervical Cancer With Checkpoint Inhibitor Therapy" has revealed significant baseline knowledge gaps in the area of checkpoint inhibitor therapies for advanced cervical cancer.Three hundred and ninety-seven learners took part in the educational activity and completed the pre-activity assessment, and 375 of these finished the activity a...
Because high blood insulin and insulin resistance are associated with increased cancer risk, cancer screening is especially important in patients with diabetes. However, a recent study has found that women with diabetes underutilize screening for breast, cervical, and colorectal cancer.Cancer screening has been shown to decrease the risk of death by up to 33% for breast cancer, 70% for cervical cancer, and 37% for colorectal cancer. By enabling early detection and treatment before the disease ha...