A new study reports that nearly a third of patients with primary brain tumors experience clinically significant body image dissatisfaction, which can negatively impact their quality of life and psychosocial well-being. Body image—a concept consisting of cognitive, emotional, and relational elements derived from one's physical appearance—plays an important role in an individual's self-esteem, relationships, and outlook on life. Due to the physical impacts of treatment, patients with cancer face a...
In patients with newly diagnosed glioblastoma, maximal extent of surgical resection of contrast-enhancing tumor has consistently been associated with benefits to survival. However, in a practice-changing study published recently in JAMA Oncology, a team of investigators under the leadership of Mitchel Berger, MD, found that extending resection to include non–contrast-enhancing tumor as well as contrast-enhancing tumor is associated with increased survival, regardless of tumor genetic subtype. I...
In patients with newly diagnosed glioblastoma, maximal extent of surgical resection of non–contrast enhanced (NCE) tumor as well as contrast-enhanced (CE) tumor is associated with increased survival regardless of tumor subtype, according to a study recently published in JAMA Oncology. Glioblastoma subtypes are known to impact disease outcome: while the 91% of patients with glioblastoma whose tumors display isocitrate dehydrogenase gene 1 or 2 (IDH) wild-type mutations have a median survival o...
Researchers have identified glioblastoma biomarkers in extracellular vesicles that could enable a liquid biopsy, serving as a more efficient and less invasive means of detecting and subtyping this cancer. The most aggressive type of brain tumor, glioblastoma has a poor survival rate and limited treatment options. While it can currently be diagnosed through tumor biopsies, this method can be time consuming, invasive, and painful. There is a need to develop more effective options for detecting gli...
One of the significant contributors to glioblastoma, a cancer of the brain and one of the most aggressive malignancies, tumor-associated macrophages have great potential as therapeutic targets; however, targeting these cells has not been effective, in part due to a limited understanding of the reasons behind their behavior. Researchers seeking to better understand this behavior have now discovered that tumor-associated macrophages are composed of two cell types: brain-resident microglia and bone...