Body Image Dissatisfaction in Patients With Primary Brain Tumors

A new study reports that nearly a third of patients with primary brain tumors experience clinically significant body image dissatisfaction, which can negatively impact their quality of life and psychosocial well-being. Body image—a concept consisting of cognitive, emotional, and relational elements derived from one's physical appearance—plays an important role in an individual's self-esteem, relationships, and outlook on life. Due to the physical impacts of treatment, patients with cancer face a...
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Resecting Non–Contrast-Enhancing Tumor in Glioblastoma: Mitchel Berger, MD

​In patients with newly diagnosed glioblastoma, maximal extent of surgical resection of contrast-enhancing tumor has consistently been associated with benefits to survival. However, in a practice-changing study published recently in JAMA Oncology, a team of investigators under the leadership of Mitchel Berger, MD, found that extending resection to include non–contrast-enhancing tumor as well as contrast-enhancing tumor is associated with increased survival, regardless of tumor genetic subtype. I...
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Maximal NCE Tumor Resection Impacts Glioblastoma Survival

​In patients with newly diagnosed glioblastoma, maximal extent of surgical resection of non–contrast enhanced (NCE) tumor as well as contrast-enhanced (CE) tumor is associated with increased survival regardless of tumor subtype, according to a study recently published in JAMA Oncology. Glioblastoma subtypes are known to impact disease outcome: while the 91% of patients with glioblastoma whose tumors display isocitrate dehydrogenase gene 1 or 2­­ (IDH) wild-type mutations have a median survival o...
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Biomarkers in Liquid Biopsies Detect Glioblastoma Tumors

Researchers have identified glioblastoma biomarkers in extracellular vesicles that could enable a liquid biopsy, serving as a more efficient and less invasive means of detecting and subtyping this cancer. The most aggressive type of brain tumor, glioblastoma has a poor survival rate and limited treatment options. While it can currently be diagnosed through tumor biopsies, this method can be time consuming, invasive, and painful. There is a need to develop more effective options for detecting gli...
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Understanding Glioblastoma Tumor-Associated Macrophages

One of the significant contributors to glioblastoma, a cancer of the brain and one of the most aggressive malignancies, tumor-associated macrophages have great potential as therapeutic targets; however, targeting these cells has not been effective, in part due to a limited understanding of the reasons behind their behavior. Researchers seeking to better understand this behavior have now discovered that tumor-associated macrophages are composed of two cell types: brain-resident microglia and bone...
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