Faulty DNA Repair in Medulloblastomas and High-Grade Gliomas

Researchers have found that medulloblastomas and high-grade gliomas, two types of brain tumors, often exhibit frequent, complex rearrangements of the genome as a result of malfunctioning DNA repair.Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) investigated the cause of chromothripsis, one of two "catastrophic genomic events" that cause genomic instability and are implicated in the development of cancer. In chromothripsis, tens to hundreds of clustered D...
Continue reading

Medulloblastoma: New Genetic Marker Differentiates Risk

Researchers have identified a new genetic marker that can be used to determine which patients with medulloblastoma have high-risk tumors in need of aggressive treatment."Medulloblastoma is the most common malignant childhood brain tumor, and it is important that we have improved outcomes for patients with this disease," commented Steve Clifford, PhD, Director of the Northern Institute for Cancer Research at Newcastle University and co-senior author of the study, which was published in Lancet Onc...
Continue reading

New Treatment Targets Chemotherapy-Resistant Brain Cancer

Researchers have demonstrated the efficacy of a new treatment targeting genetic mutations in patients with chemotherapy-resistant secondary glioblastoma (sGBM), a rare and deadly form of brain cancer.Low-grade gliomas progress into sGBM, which has limited treatment options and a 5-year survival rate under 10%. Secondary glioblastoma is treated with temozolomide (TMZ), a chemotherapy drug. Upon relapse, which happens in most patients, genetic mutations enable sGBM tumors to resist the drug's effe...
Continue reading

Does Cell Phone Radiation Cause Cancer? National Toxicology Program Reports

In the culmination of 10 years of research, the National Toxicology Program (NTP) has now released its final reports concerning the effects on rats and mice of radiofrequency radiation (RFR) with modulations used in 2G and 3G cell phone networks.In conjunction with a panel of external scientific experts who reviewed the reports, the NTP determined that there is clear evidence that high levels of RFR like that of 2G and 3G cell technologies caused cancerous heart tumors in male rats. They conclud...
Continue reading

Bigger Brain, Bigger Risk of Brain Cancer

Researchers at the Norwegian University of Science and Technology (NTNU) have found that larger brain size, as measured by intracranial volume, puts individuals at increased risk of glioma, the most common type of primary brain tumor.Gliomas, which occur in the brain and spinal cord, originate in glial stem cells. Their cause is unknown. Epidemiological studies have identified several risk factors, including age (gliomas are most commonly seen in adults), male sex, ionizing radiation, white...
Continue reading

Copyright © 2020 i3 Health. All rights reserved.