Pediatric Brain Tumors: Cognitive Effects in Adulthood

Children with central nervous system (CNS) tumors have good prognoses; 75% will live at least five years after diagnosis. Unfortunately, a recent study has shown that these survivors experience neuropsychological problems and lower socioeconomic status later in life compared with their healthy peers.For this study, published in Cancer, the researchers analyzed data on 181 adult survivors of pediatric low-grade gliomas from the Childhood Cancer Survivor Study and compared them with a group of 105...
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Using Surgical Smoke to Detect Brain Malignancies

Electrosurgical resection, a common neurosurgery technique done with an electric knife or diathermy blade, produces surgical smoke, called diathermy smoke, from the burning of tissue during the procedure. Researchers in Finland have developed a device that can identify cancerous brain tissue based on properties of the diathermy smoke. This device could enable a surgeon to more quickly and accurately identify malignant tissue during brain cancer surgery in order to ensure that all parts...
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Tozuleristide Enables Fluorescence-Guided Surgery in Glioma

​For patients with gliomas, tumors that begin in the glial cells of the brain and spinal cord, fluorescence-guided surgery (FGS) can improve the extent of surgical resection by enabling neurosurgeons to better see the margins of the malignancies that they are trying to remove. A recent study has revealed that when used with a new, high-sensitivity near-infrared camera, tozuleristide (BLZ-100) provides effective imaging for FGS in adults with newly diagnosed or recurrent gliomas.The high-sensitiv...
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ALK2 Inhibitors: Hope for Incurable Childhood Glioma

​Researchers have found two activin receptor-like kinase 2 (ALK2) inhibitors that show promise in treating preclinical models of ACVR1-mutant diffuse intrinsic pontine glioma (DIPG).An incurable childhood tumor of the brain stem, DIPG has a median overall survival of nine to 12 months. The chemotherapy treatments most commonly used in histologically similar tumors found in other areas of the brain do not work with DIPG; the only treatment that produces a response is radiotherapy. Within two year...
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Lifetime Brain Metastasis Risk in Older Patients With Cancer

Older adults with lung, breast, and skin cancers have an increased risk of developing brain metastasis during their lifetime. But how big is this risk? In an effort to find out, researchers used data from the Surveillance, Epidemiology, and End Results (SEER) Program on patients with lung cancer, breast cancer, or melanoma diagnosed with a brain metastasis, either one identified during primary cancer staging workup, called a synchronous brain metastasis (SBM), or one detected later in life, call...
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