How Genetic Testing Results Impact Breast Cancer Treatment: Allison Kurian, MD, MSc

​With our ever-growing understanding of mutations that increase cancer risk and the rise of targeted treatments such as poly (ADP-ribose) polymerase (PARP) inhibitors that are indicated for specific mutations, the use of germline genetic testing for patients with breast cancer has increased significantly in recent years. How are these test results affecting patients' treatment? In a population-based cohort study published recently published in JAMA Oncology, Allison W. Kurian, MD, MSc, and colle...
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The Effect of Germline Mutations on Breast Cancer Treatment

Patients with breast cancer for whom germline genetic testing reveals pathogenic mutations often receive treatment that deviates from standard therapeutic guidelines, according to results of a population-based cohort study published today in JAMA Oncology.The use and importance of germline genetic testing for patients with cancer has increased in recent years as our understanding has grown regarding mutations that increase cancer susceptibility and as targeted treatments such as poly ADP ribose ...
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Insurance Status Contributes to Racial Disparities in Breast Cancer

A new study reports that a lack of adequate health insurance is responsible for nearly half of racial and ethnic disparities in breast cancer stage at diagnosis.Earlier detection and treatment of breast cancer can significantly improve outcomes for patients diagnosed with this disease. However, studies have shown that a higher proportion of women of racial and ethnic minorities present with breast cancer at more advanced stages, negatively impacting their treatment and prognosis. In a study now ...
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Antioxidant Supplements Worsen Breast Cancer Outcomes

An analysis of a phase 3 trial found that taking antioxidants and other dietary supplements during chemotherapy can decrease survival and increase the risk of recurrence in patients with breast cancer.Antioxidants such as vitamins A, C, and E, carotenoids, and coenzyme Q10 occur naturally in fruits, vegetables, and whole grains, but many patients with cancer take additional vitamins and minerals to supplement their diets while undergoing treatment. However, recent research has shown that antioxi...
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New FDA Approval for Relapsed/Refractory HER2-Positive Metastatic Breast Cancer

​The FDA has now granted accelerated approval to fam-trastuzumab deruxtecan-nxki (Enhertu®, Daiichi Sankyo) for patients with unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer previously treated with at least two anti-HER2–based regimens in the metastatic setting. Fam-trastuzumab deruxtecan-nxki, otherwise known as trastuzumab deruxtecan, is an antibody-drug conjugate consisting of an anti-HER2 antibody, a cleavable tetrapeptide-based linker, and a...
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