Metastatic Colorectal Cancer: Treatment Challenges, Progress, and Advice With Chiara Cremolini, MD

Colorectal cancer is the third leading cause of cancer death and the fourth most common diagnosed cancer in the world. Often, this disease is left undiagnosed until it reaches an advanced stage. Unfortunately, late-stage metastatic colorectal cancer has a poor prognosis with a 5-year survival rate of only 12%. In an interview with i3 Health, Chiara Cremolini, MD, provides insights on the challenges of treating patients with metastatic colorectal cancer, explains how metastatic colorectal cancer ...
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FOLFOXIRI Efficacy in Metastatic Colorectal Cancer: Chiara Cremolini, MD

Results of TRIBE2, a phase 3 trial (NCT02339116), show that the triplet treatment FOLFOXIRI (fluorouracil/leucovorin/oxaliplatin/irinotecan) plus bevacizumab is more effective at treating patients with metastatic colorectal cancer than FOLFIRI (irinotecan/leucovorin/fluorouracil) plus bevacizumab. In an interview with i3 Health, Chiara Cremolini, MD, lead researcher of this study, provides insights on the results of this trial as well as how the future of treatment for metastatic colorectal canc...
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FOLFOXIRI Combo Effective for Metastatic Colorectal Cancer?

According to the results of TRIBE2, a phase 3 trial (NCT02339116), the triplet treatment FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) in combination with bevacizumab has been shown to be more effective in treating patients with metastatic colorectal cancer before and after disease progression compared with sequential administration of chemotherapy doublets plus bevacizumab. Patients aged 18 to 75 years with an Eastern Cooperative Oncology Group (ECOG) performance status of 2...
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RNF43 Variation and Cetuximab Efficacy in Metastatic Colorectal Cancer: Francesca Battaglin, MD

‚ÄčIn metastatic colorectal cancer, there has been a concerted effort to identify biomarkers that can predict the efficacy of existing treatments and support the development of new targeted therapies. As part of these efforts, Francesca Battaglin, MD, and colleagues investigated the association between cetuximab efficacy and gene expression levels and genetic variants in the R-Spondin/RNF43 complex. For their analysis, the researchers used genomic DNA from blood samples of participants in the phas...
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BRAF V600E-Mutant Colorectal Cancer: Triplet and Doublet Therapies Improve Quality of Life

An updated analysis of a phase 3 trial reports that encorafenib/cetuximab, alone or in combination with binimetinib, improves quality of life compared with the current standard of care in patients with BRAF V600E-mutant metastatic colorectal cancer whose disease progressed after one or two prior therapies.The BEACON CRC study, the results of which were published in the New England Journal of Medicine in October, investigated the efficacies of encorafenib/cetuximab/binimetinib (triplet therapy) a...
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