Colorectal Cancer Diagnoses on the Rise in Younger Patients

Researchers from the University of Texas at Austin have determined that diagnoses of colorectal cancer are increasing in patients under 50 years of age. While new guidelines from the American Cancer Society recommend that average-risk adults begin undergoing regular screening for colorectal cancer at age 45, many physicians do not begin referring patients for screening – either colonoscopy or alternatives such as fecal immunochemical tests or fecal occult blood tests – until age 50. The study pu...
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​Safe Dose of Regorafenib For Metastatic Colorectal Cancer

In patients with refractory metastatic colorectal cancer, regorafenib (Stivarga®, Bayer) provides a good overall survival benefit. Unfortunately, it also causes a lot of side effects, such as infection, severe bleeding, tears in the stomach or intestinal wall, hand-foot skin reaction, severe skin rash, high blood pressure, decreased blood flow to the heart, heart attack, reversible posterior leukoencephalopathy syndrome, and wound healing problems, all of which limit its usefulness. In order to ...
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Could Strawberry Tree Honey Fight Colon Cancer?

Researchers report that strawberry tree honey, a typical food in the Mediterranean region, has cancer-fighting potential in colon adenocarcinoma, the most common form of colorectal cancer. For the study, which has now been published in the Journal of Functional Foods , the investigators researched both the phytochemical composition and the anticancer effects of honey from the strawberry tree ( Arbutus unedo ) on cellular proliferation, cell cycle, and apoptosis—programmed cell death—in two types...
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Colorectal Cancer: MEK Inhibitors Promote Resistance

Forty-five percent of colorectal cancers are driven by mutations causing overactivation of the Ras signaling pathway. MEK inhibitors mitigate this overactivation, so why are they ineffective in the treatment of colorectal cancer? Researchers at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now found a possible explanation: in colorectal cancer, MEK inhibitors activate signaling of the Wnt pathway, thereby causing stem c...
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Should Patients Take Aspirin Before Colorectal Screening?

Fecal immunochemical tests measure the level of hemoglobin in a patient's blood in order to help determine if they may have colorectal cancer. Prior studies have suggested the possibility that a single dose of oral aspirin taken before the test may help fecal immunochemical tests to detect advanced colorectal neoplasms more effectively. To test this notion, researchers compared a group of patients who took aspirin before their test to a group of patients who took a placebo before their test and ...
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