Apalutamide Approved for Metastatic Castration-Sensitive Prostate Cancer

The FDA has approved apalutamide (Erleada®, Janssen Biotech, Inc.) in combination with androgen deprivation therapy (ADT) for patients with metastatic castration-sensitive prostate cancer (CSPC). The approval was based on TITAN (NCT02489318), a randomized, double-blind, placebo-controlled, multicenter clinical trial that enrolled 1,052 patients with metastatic CSPC, including patients with both high- and low-volume disease. Prior treatment for localized disease and prior docetaxel therapy were a...
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Educational Need in Castration-Resistant Prostate Cancer

Due to the increase in treatment options for castration-resistant prostate cancer (CRPC) in recent years, some confusion exists over the optimal therapeutic approach. A number of factors must be considered in CRPC treatment, including patient health status, rate of disease progression and disease burden, presence of bone or visceral metastases, mechanism of action and tolerability of available agents, and prior lines of therapy and response. Baseline data collected from i3 Health's continuing me...
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Treating Cisplatin-Ineligible Metastatic Urothelial Carcinoma: Sarmad Sadeghi, MD, PhD

For many patients with metastatic urothelial carcinoma, cisplatin-containing chemotherapy is not an option; alternative treatments are greatly needed. Recently, the phase 2 California Cancer Consortium trial, led by Sarmad Sadeghi, MD, PhD, reported that a combined regimen of gemcitabine (Gemzar®, Eli Lilly) and eribulin (Halaven®, Eisai Inc.) demonstrates efficacy in cisplatin-ineligible patients with metastatic urothelial carcinoma. In this interview with i3 Health, Dr. Sadeghi discusses the i...
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The Mortality Risk of Androgen Inhibitors for Prostate Cancer and Heart Disease: An Interview With Grace Lu-Yao, PhD, MPH

Abiraterone acetate and enzalutamide are oral androgen signaling inhibitor therapies used in the treatment of patients with advanced prostate cancer. However, because elderly patients with prostate cancer who also have cardiovascular disease are often excluded from clinical trials, little has been known about the effect of these therapies on the clinical outcomes of these patients. In this interview with i3 Health, Grace Lu-Yao, PhD, MPH, discusses the increased mortality and hospitalization ris...
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Androgen Inhibitors for Prostate Cancer and Heart Disease

Abiraterone acetate and enzalutamide, two oral androgen signaling inhibitor therapies, have been found to increase mortality in elderly patients with advanced prostate cancer and pre-existing cardiovascular disease (CVD). Many of the clinical trials which led to the approval of abiraterone acetate and enzalutamide for the treatment of advanced prostate cancer excluded elderly patients, defined as those age 65 and older, with cardiovascular comorbidities, such as congestive heart failure, atrial ...
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