Osimertinib for EGFR-Mutated Advanced NSCLC: An Interview with Suresh S. Ramalingam, MD

The treatment of advanced-stage non-small cell lung cancer (NSCLC) has improved steadily in the past few years, and individualized therapy for patients with mutations in the epidermal growth factor receptor (EGFR) is applied in routine clinical practice. While EGFR-mutated NSCLC is effectively treated with tyrosine kinase inhibitors (TKIs) such as erlotinib or gefitinib, there is a need to develop more effective treatments to improve outcomes in these patients. In a study now published in The Ne...
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The Deadly Consequences of Fine Particle Air Pollution

A new study finds an association between fine particulate matter (PM 2.5 ) air pollution and deaths from nine different causes, including cardiovascular disease, cerebrovascular disease, hypertension, dementia, and lung cancer, among others. Furthermore, 99% of PM 2.5 -associated deaths were linked to levels of PM 2.5 exposure currently deemed acceptable by US Environmental Protection Agency (EPA) recommendations. Atmospheric particulate matter with a diameter of less than 2.5 micrometers, PM 2....
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Racial, Age-Related Disparities in Lung Cancer Treatment

A new study reports that only 62.1% of US patients with lung cancer receive treatment that adheres to guidelines, and elderly and non-Hispanic black patients are disproportionately represented among those whose cancer is undertreated. For the study, now published in Annals of the American Thoracic Society , the researchers evaluated whether 441,812 lung cancer cases in the US National Cancer Database diagnosed between 2010 and 2014 received treatment that adhered to the National Comprehensive Ca...
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Yogurt and Fiber Intake May Reduce Lung Cancer Risk

Researchers have discovered that consuming more dietary fiber and yogurt decreases an individual's chance of developing lung cancer. Yogurt, a probiotic food, and dietary fiber, a huge source of prebiotics, offer many health benefits by modulating the gut microbiota and metabolic pathways. "Our findings have no immediate clinical impacts on [patients with] lung cancer, but do have a major public health impact on lung cancer prevention," stated lead researcher, Xiao-Ou Shu, MD, PhD, Professor of ...
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Tumor Treating Fields Plus Chemo Effective for Mesothelioma

By delivering low-intensity alternating electric fields, Tumor Treating Fields (TTFields), a regional, antimitotic therapy, has been deemed effective in treating solid tumors. Researchers set out to discover if TTFields would be successful in combination with systemic chemotherapy for treatment-naive patients with unresectable malignant pleural mesothelioma. For this phase 2 study, published in The Lancet Oncology, the investigators enrolled 80 patients from 12 European academic and non-academic...
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