Cancer Vaccine Attacks Multiple Targets for Better Results

In a strategy that may prevent tumors from eluding the immune system's attack, researchers have developed a new cancer vaccine capable of targeting multiple members of a cancer-causing family of proteins at once. Because proteins in the melanoma-associated antigen (MAGE-A) family are highly tumor specific and are overexpressed in several types of cancer, they have become a focus of recent immunotherapy research efforts. Yet melanoma and lung carcinoma investigations of MAGE-A3, a MAGE-A isoform ...
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Experimental Cancer Vaccine Combination Is Effective Against Melanoma

Researchers have identified and optimized a synthetic chemical adjuvant that enhances an experimental cancer vaccine, enabling it to treat aggressive melanoma and immunize against its recurrence. For cancer immunotherapy to succeed, it must cause tumor antigen-specific cytotoxic T lymphocytes (CTLs) to activate, augmenting the body's own cancer-fighting ability. An adjuvant can strengthen this adaptive immune response, enhancing the body's attack on cancer antigens. Diprovocim, the adjuvant...
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