Adjuvant Chemo Improves Survival in Node-Positive Pancreatic Cancer

Pancreatic cancer has a dismal prognosis with a 5-year survival rate of 9%. Even after upfront surgical resection combined with adjuvant chemotherapy, 75% of patients relapse within 2 years. However, results from a recent study show that adjuvant chemotherapy can improve outcomes in patients with pathology-proven node-positive pancreatic cancer who received neoadjuvant folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) and resection, providing a potential new standard of care t...
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Olaparib Approval: BRCA-Mutated Metastatic Pancreatic Cancer

The FDA has now approved olaparib (Lynparza®, AstraZeneca) for the maintenance treatment of adults with deleterious or suspected deleterious germline BRCA-mutated metastatic pancreatic adenocarcinoma who have not experienced disease progression after at least 16 weeks of a first-line platinum-based chemotherapy regimen. In addition, the FDA approved the BRACAnalysis CDx test (Myriad Genetic Laboratories, Inc.) as a companion diagnostic for the selection of patients with deleterious or suspected ...
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Epidermal Growth Factor Ointment for Skin Toxicities: An Interview With Sung Yong Oh, MD, PhD

By inhibiting epidermal growth factor receptor (EGFR) signaling pathways, EGFR inhibitors have shown efficacy in the treatment of a variety of cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, and colorectal cancer. However, most patients who receive EGFR inhibitors develop adverse skin events, such as acneiform rash, xerosis, paronychial inflammation, pruritis, photosensitivity, and hair and eyelash alteration. If not properly managed, these toxicities can lead to physic...
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Epidermal Growth Factor Ointment Relieves Skin Toxicities

A new study reports that epidermal growth factor (EGF) ointment is effective in managing skin toxicities and improving quality of life in patients treated with epidermal growth factor receptor (EGFR) inhibitors. By inhibiting EGFR signaling pathways, which play a role in the pathogenesis and progression of a variety of cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, and colorectal cancer, EGFR tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies are effective ...
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Perioperative Chemotherapy, a New Approach to Pancreatic Cancer: An Interview With Alice C. Wei, MD, MSc

The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) has limited treatment options and a low survival rate. Traditionally, patients whose disease is resectable—able to be removed by surgery—have been treated with a post-operative adjuvant approach, consisting of surgery followed by chemotherapy or radiation. In recent years, however, there has been a heightened interest in perioperative treatment, in which patients receive chemotherapy or radiation both before and a...
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