Has Life Expectancy for Adult Survivors of Childhood Cancer Improved?

Scientists recently discovered that improved cancer treatment approaches over time correlate with higher life expectancy in adult survivors of childhood cancer.As cancer treatment evolves to be more effective, more patients are surviving, with some even living long lives disease free. In order to determine if life expectancy also rises with evolving treatment, the investigators examined data derived from the Childhood Cancer Survivor Study, which included data on 5-year survivors of childhood ca...
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In High-Risk Neuroblastoma, Tandem Transplant Is Superior

A randomized clinical trial reports that in patients with neuroblastoma, tandem autologous stem cell transplant improves outcomes compared with single transplant.Neuroblastoma, a malignancy of the developing sympathetic nervous system, is responsible for around 10% to 12% of childhood cancer deaths. For the 43% of patients who present with high-risk disease, which involves either widespread metastasis in patients over the age of 18 months and/or amplification of the MYCN oncogene, the standard o...
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Analysis Reveals Substantial Childhood Cancer Burden

As technology and health care progress, the rate of children who survive five years after being diagnosed with cancer is 80%; however, this rate only applies to children who live in high-income countries (HICs). Those children that live in low-income and middle-income countries (LMICs) make up more than 90% of children who are at risk of developing cancer, and, unfortunately, children who live in LMICs lack the resources necessary to combat childhood cancer compared with children who live in HIC...
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JMJD6 Identified as a Neuroblastoma Tumorigenic Factor

Researchers have identified the JMJD6 gene as a critical factor for neuroblastoma tumorigenesis, indicating potential for a new targeted drug therapy treatment strategy.The most prevalent solid tumor in early childhood cancers, neuroblastoma comprises 15% of total childhood cancer deaths. Neuroblastoma is distinctive from adult cancers in that it is characterized by frequent chromosome copy number variations, and its most prominent features are gene deletion, amplification, or gain. While chromo...
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Birth Defects and Pediatric Cancer: An Interview With Philip J. Lupo, PhD, MPH

‚ÄčIn their recently published study, Philip J. Lupo, PhD, MPH, and colleagues found that both chromosomal anomalies and nonchromosomal birth defects significantly increase a child's risk of receiving a cancer diagnosis before his or her 18th birthday. In this interview with i3 Health, Dr. Lupo discusses his findings and the future directions of this research.Can you comment on the significance of your results concerning the link between birth defects and pediatric cancer risk?Philip J. Lupo, PhD,...
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