Analysis Reveals Substantial Childhood Cancer Burden

As technology and health care progress, the rate of children who survive five years after being diagnosed with cancer is 80%; however, this rate only applies to children who live in high-income countries (HICs). Those children that live in low-income and middle-income countries (LMICs) make up more than 90% of children who are at risk of developing cancer, and, unfortunately, children who live in LMICs lack the resources necessary to combat childhood cancer compared with children who live in HIC...
Continue reading

JMJD6 Identified as a Neuroblastoma Tumorigenic Factor

Researchers have identified the JMJD6 gene as a critical factor for neuroblastoma tumorigenesis, indicating potential for a new targeted drug therapy treatment strategy. The most prevalent solid tumor in early childhood cancers, neuroblastoma comprises 15% of total childhood cancer deaths. Neuroblastoma is distinctive from adult cancers in that it is characterized by frequent chromosome copy number variations, and its most prominent features are gene deletion, amplification, or gain. While chrom...
Continue reading

Birth Defects and Pediatric Cancer: An Interview With Philip J. Lupo, PhD, MPH

​ In their recently published study, Philip J. Lupo, PhD, MPH, and colleagues found that both chromosomal anomalies and nonchromosomal birth defects significantly increase a child's risk of receiving a cancer diagnosis before his or her 18th birthday. In this interview with i3 Health, Dr. Lupo discusses his findings and the future directions of this research. Can you comment on the significance of your results concerning the link between birth defects and pediatric cancer risk? Philip J. Lupo, P...
Continue reading

Pediatric Brain Tumors: Cognitive Effects in Adulthood

Children with central nervous system (CNS) tumors have good prognoses; 75% will live at least five years after diagnosis. Unfortunately, a recent study has shown that these survivors experience neuropsychological problems and lower socioeconomic status later in life compared with their healthy peers. For this study, published in Cancer, the researchers analyzed data on 181 adult survivors of pediatric low-grade gliomas from the Childhood Cancer Survivor Study and compared them with a group of 10...
Continue reading

Birth Defects Linked to Childhood Cancer

Both chromosomal anomalies and nonchromosomal birth defects substantially increase the risk of childhood cancer, a new study reports. Around one in 33 children has a birth defect. Some birth defects have already been linked to childhood cancer. For example, trisomy 21—the presence of an extra #21 chromosome, which causes Down syndrome—is associated with acute leukemia. However, an overall determination of increase in childhood cancer risk in those with birth defects has been limited by small sam...
Continue reading

© Copyright 2019 i3 Health. All rights reserved.