Novel Treatments for High-Risk Rectal Adenocarcinoma: Carlos Fernández-Martos, MD

​Carlos Fernández-Martos, MD, and colleagues recently reported that in patients with high-risk, locally advanced rectal adenocarcinoma, adding aflibercept (Zaltrap®, Regeneron Pharmaceuticals, Inc.) to a modified schedule of fluorouracil/leucovorin/oxaliplatin (FOLFOX6) followed by standard chemoradiotherapy and total mesorectal excision surgery increased treatment efficacy, producing a higher complete pathologic response rate. In this interview with i3 Health, Dr. Fernández-Martos discusses the...
Continue reading

How Being Unmarried Impacts Cancer Treatment: An Interview With Joan DelFattore, PhD, MS

Studies have shown that unmarried patients with cancer are less likely to receive surgery and radiotherapy than their married counterparts; they are also less likely to survive their cancer. In a research-based perspective essay published in The New England Journal of Medicine, Joan DelFattore, PhD, MS, a survivor of stage IV gallbladder cancer, suggests that contrary to assumptions made by a number of researchers, the disparities in cancer treatment for individuals who are single may stem not f...
Continue reading

Proton Therapy for Breast Cancer With Rachel B. Jimenez, MD

While conventional radiation therapy can be effective for patients with breast cancer, it carries with it risk of damage to the heart and lungs. Proton beam radiotherapy, a specialized type of external beam radiation that precisely targets a tumor with high doses of radiation while minimizing damage to nearby tissue and critical organs, shows promise as an alternative for some patients. In a phase 2 study published recently in the Journal of Clinical Oncology, a team of researchers at Massachuse...
Continue reading

Perioperative Chemotherapy, a New Approach to Pancreatic Cancer: An Interview With Alice C. Wei, MD, MSc

The most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) has limited treatment options and a low survival rate. Traditionally, patients whose disease is resectable—able to be removed by surgery—have been treated with a post-operative adjuvant approach, consisting of surgery followed by chemotherapy or radiation. In recent years, however, there has been a heightened interest in perioperative treatment, in which patients receive chemotherapy or radiation both before and a...
Continue reading

Treating Triple-Class Refractory Myeloma With Ajai Chari, MD

​With increasing frequency, multiple myeloma is becoming triple-class refractory, or refractory to all three primary classes of drugs used in its treatment. What is to be done in such cases? In the phase 2b STORM study, now published in The New England Journal of Medicine, Ajai Chari, MD, and colleagues report that a combination of oral selinexor and dexamethasone shows efficacy in patients with triple-class refractory disease. In this interview with i3 Health, Dr. Chari discusses the importance...
Continue reading

Copyright © 2020 i3 Health. All rights reserved.