The Mortality Risk of Androgen Inhibitors for Prostate Cancer and Heart Disease: An Interview With Grace Lu-Yao, PhD, MPH

Abiraterone acetate and enzalutamide are oral androgen signaling inhibitor therapies used in the treatment of patients with advanced prostate cancer. However, because elderly patients with prostate cancer who also have cardiovascular disease are often excluded from clinical trials, little has been known about the effect of these therapies on the clinical outcomes of these patients. In this interview with i3 Health, Grace Lu-Yao, PhD, MPH, discusses the increased mortality and hospitalization ris...
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Utilizing Proper Supportive Care in Multiple Myeloma: An Interview With Smith Giri, MD, MHS

​In the treatment of multiple myeloma, supportive care is essential to mitigating the risks of infection and bone disease. However, a study published recently in Cancer by Smith Giri, MD, MHS, and colleagues found that guideline-recommended supportive care measures are underutilized in older patients with multiple myeloma. In this interview with i3 Health, Dr. Giri discusses supportive care for patients with myeloma, as well as interventions that could increase the use of these measures.Can you ...
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Immuno-Oncology and Checkpoint Inhibition in Cervical Cancer: Bradley Monk, MD, FACS, and Ramez Eskander, MD

​Unlike that of other gynecological malignancies, the etiology of cervical cancer is the human papillomavirus (HPV). This fact plays a role in how cervical cancer is perceived as immunogenic: T cells themselves are involved in the immune response and in the control of viral infections and the development of these tumors. In this discussion with i3 Health, Bradley Monk, MD, FACS, FACOG, Professor of Gynecologic Oncology at the University of Arizona and Creighton University, and Ramez Eskander, MD...
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Pembrolizumab for Advanced Esophageal Squamous Cell Carcinoma: An Interview with Ken Kato, MD

On July 30, 2019, the FDA approved pembrolizumab (Keytruda®, Merck) for patients with recurrent locally advanced or metastatic squamous cell carcinoma of the esophagus (ESCC) whose tumors expressed a programmed death-ligand 1 (PD-L1) combined positive score (CPS) of at least 10 and whose disease progressed after at least one line of systemic therapy. The approval was based on two clinical trials. One of these was Keynote-181, which enrolled 628 patients with locally advanced or metastatic ESCC w...
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Optimizing Prostate Cancer Detection: Interview With Johannes Czernin, MD

There is a discrepancy in guideline recommendations regarding prostate cancer detection; National Comprehensive Cancer Network (NCCN) guidelines recommend using 18F-fluciclovine PET-CT for prostate cancer biochemical recurrence localization after radical prostatectomy as opposed to European Association of Urology (EAU) guidelines, which recommend prostate-specific membrane antigen (PSMA) PET-CT. Jeremie Calais, MD, Johannes Czernin, MD, and colleagues compared using 18F-fluciclovine PET-CT versu...
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