Vitamin D Supplements May Reduce the Risk of Developing Advanced Cancer

In individuals without cancer, vitamin D supplementation may decrease the risk of developing advanced cancer, especially for those with a normal body mass index (BMI), according to a recent analysis of a phase 3 trial. "Vitamin D may decrease tumor invasiveness and propensity to metastasize, leading to reduced cancer mortality," write the investigators, led by first author Paulette D. Chandler, MD, MPH, Assistant Professor of Medicine at Harvard Medical School. "Vitamin D may have a role in redu...
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Caregivers Need Care, Too: An Interview With Supriya G. Mohile, MD, MS

Caregivers, especially those caring for older patients with advanced cancers, are under immense stress taking care of their loved ones. Supriya G. Mohile, MD, MS, The Philip and Marilyn Wehrheim Professor at the University of Rochester, and colleagues revealed in a study that caregivers of older patients with advanced cancers experience higher levels of distress, anxiety, and depression compared with the general population. In this interview with i3 Health, Dr. Mohile shares insights regarding t...
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PARP Inhibitor Effective in Advanced Pancreatic Cancer

Poly (ADP-ribose) polymerase (PARP) inhibitors, such as rucaparib (Rubraca®, Clovis Oncology), have been shown to be effective for cancers containing BRCA mutations. They have also been successful as maintenance therapy for platinum-sensitive ovarian cancer treated with PARP inhibitors. Therefore, researchers conducted a phase 2 clinical trial to determine if patients with platinum-sensitive advanced pancreatic cancer and a pathogenic germline or somatic BRCA or PALB2 mutation whose cancer had n...
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Caring for Older Patients With Advanced Cancers Affects Caregivers’ Emotional Health

For many informal caregivers, providing assistance to loved ones with cancer is emotionally taxing, especially for those taking care of older patients with advanced cancers. Researchers set out to better understand the relationship between older patients with cancer and their caregivers' mental health and quality of life (QOL) and found that caring for older patients with advanced cancers negatively impacts caregivers' emotional health. In a clinical trial, published in the Journal of the Americ...
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Overprescribing Preventive Drugs to Elderly Patients With Advanced Cancer

Researchers discovered that elderly patients with advanced cancer who continue to take some preventive drugs might not achieve clinical benefit during their remaining lifespan, thereby rendering the drugs unnecessary money and time wasters. In this study, published in Cancer, the investigators found that in 151,201 adults older than 65 with advanced cancer who passed away, patients were prescribed an average of 6.9 to 10.1 drugs over the last year of their life. Preventive drugs, such as antihyp...
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