Could E-Cigarettes Cause Bladder Cancer?

According to the results of a recently published study, carcinogenic biomarkers strongly linked to bladder cancer risk are found in the urine samples of electronic cigarette (e-cigarette) users.E-cigarettes contain nicotine, additives, and other chemical solvents that can create numerous toxic compounds when heated. Their popularity has increased dramatically in recent years, especially in the adolescent and young adult population. Between 2017 and 2018, usage increased nearly 80% among high sch...
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Biomarkers in Liquid Biopsies Detect Glioblastoma Tumors

Researchers have identified glioblastoma biomarkers in extracellular vesicles that could enable a liquid biopsy, serving as a more efficient and less invasive means of detecting and subtyping this cancer.The most aggressive type of brain tumor, glioblastoma has a poor survival rate and limited treatment options. While it can currently be diagnosed through tumor biopsies, this method can be time consuming, invasive, and painful. There is a need to develop more effective options for detecting glio...
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Entrectinib: FDA Approved for NTRK-Fusion Positive Cancer

Entrectinib (Rozlytrek™, Genentech, Inc.) has just been FDA approved for use as treatment for patients with cancers containing neurotrophic tyrosine receptor kinase (NTRK) gene fusion, which is a genetic defect. This drug is to be used if there are no other effective treatments available.This approval marks the third time the FDA has approved a cancer drug based on a biomarker instead of tumor type. These types of approvals are beginning a paradigm in the development of cancer treatments for "ti...
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Which Biomarker Modalities Best Predict Immunotherapy Response?

In order to help predict how tumors will respond to anti–PD-1 (programmed cell death 1)/PD-L1 (programmed cell death ligand-1) therapies, doctors assess patients using PD-L1 immunohistochemistry (IHC), tumor mutational burden (TMB), gene expression profiling (GEP), and multiplex immunohistochemistry/immunofluorescence (mIHC/IF). However, the diagnostic performance of these tests has not been established. To bridge this education gap, researchers conducted a systematic review to determine the acc...
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Using Urine Biomarkers to Detect Aggressive Prostate Cancer

Through microRNAs, researchers have created a non-invasive, biomarker-based test that enables early detection of aggressive prostate cancer using a urine sample."We currently do not have accurate biomarkers to help determine the aggressiveness of prostate cancers that are not invasive," remarked Paul Boutros, PhD, Director of Cancer Data Science at the University of California, Los Angeles (UCLA) Jonsson Comprehensive Cancer Center and senior author of the study, which has now been published in ...
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