Using Surgical Smoke to Detect Brain Malignancies

Electrosurgical resection, a common neurosurgery technique done with an electric knife or diathermy blade, produces surgical smoke, called diathermy smoke, from the burning of tissue during the procedure. Researchers in Finland have developed a device that can identify cancerous brain tissue based on properties of the diathermy smoke. This device could enable a surgeon to more quickly and accurately identify malignant tissue during brain cancer surgery in order to ensure that all parts...
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Tozuleristide Enables Fluorescence-Guided Surgery in Glioma

​For patients with gliomas, tumors that begin in the glial cells of the brain and spinal cord, fluorescence-guided surgery (FGS) can improve the extent of surgical resection by enabling neurosurgeons to better see the margins of the malignancies that they are trying to remove. A recent study has revealed that when used with a new, high-sensitivity near-infrared camera, tozuleristide (BLZ-100) provides effective imaging for FGS in adults with newly diagnosed or recurrent gliomas.The high-sensitiv...
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ALK2 Inhibitors: Hope for Incurable Childhood Glioma

​Researchers have found two activin receptor-like kinase 2 (ALK2) inhibitors that show promise in treating preclinical models of ACVR1-mutant diffuse intrinsic pontine glioma (DIPG).An incurable childhood tumor of the brain stem, DIPG has a median overall survival of nine to 12 months. The chemotherapy treatments most commonly used in histologically similar tumors found in other areas of the brain do not work with DIPG; the only treatment that produces a response is radiotherapy. Within two year...
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In Ependymoma, Post-Surgery Radiation Increases Survival

​A phase 2 clinical trial reports that for children with ependymoma, the third most common pediatric brain tumor, radiation immediately following surgical resection substantially increases survival, even improving outcomes for children under the age of three."Historically, children under the age of three with ependymoma have a worse prognosis than older children," said Thomas E. Merchant, DO, PhD, Chair of the Department of Radiation Oncology at St. Jude Children's Research Hospital and first au...
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Grouped MicroRNAs Fight Glioblastomas

MicroRNAs—strings of nucleotides that bind to and destroy messenger RNA to prevent the production of certain proteins—have been discovered to play an important role in cancer and other diseases. However, in previous preclinical trials, microRNA cancer treatments lacked efficacy.In recent developments, scientists at Brigham and Women's Hospital and Harvard Medical School grouped micro-RNA molecules together, encoding them in a small, artificial gene, and then infiltrated cancer cells to overprodu...
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