In HER2-Negative Metastatic Breast Cancer, Adding CDK4/6 Inhibitor to Endocrine Therapy Helps Survival

 Endocrine therapy plus cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors improved overall survival, progression-free survival, and objective response rate for patients with hormone receptor–positive, HER2-negative metastatic breast cancer, according to results of a meta-analysis published recently in JAMA Oncology. The finding supports continued use of endocrine therapy plus CDK4/6 inhibitor combinations in clinical trials. The investigators, led by first author Jinming Li, BD, a pr...
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Does Adjuvant Chemotherapy Benefit Small, Node-Negative TNBC?

Researchers set out to investigate the association between adjuvant chemotherapy and outcomes in patients with small, node-negative, triple-negative breast cancer (TNBC) and found that whereas adjuvant chemotherapy was associated with increased overall survival (OS) in older patients with pT1b tumors, younger patients with pT1a tumors experienced higher rates of mortality. For this observational study, results of which are published in JAMA Oncology, 16,180 patients from the National Cancer Data...
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FDA Alert: Atezolizumab/Paclitaxel Ineffective for Triple-Negative Breast Cancer

The FDA has issued an alert regarding the combination of atezolizumab (Tecentriq®, Genentech) and paclitaxel for the treatment of patients with previously untreated, inoperable locally advanced or metastatic triple-negative breast cancer (TNBC). In addition to being ineffective, atezolizumab/paclitaxel can negatively impact overall survival. While atezolizumab/paclitaxel is not approved for the treatment of breast cancer, atezolizumab in combination with paclitaxel protein-bound particles, also ...
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Researchers Find Why Early Puberty Increases Breast Cancer Risk

A growing body of evidence has found a link between early puberty and increased risk of breast cancer later in life. A study published today in the Journal of Adolescent Health has given new insights as to how this association occurs. In 2004, the longitudinal study recruited 183 girls, aged six to seven years old, and followed their pubertal maturation through 2018, measuring age at onset of puberty, adult height, peak height velocity, and hormonal factors that have been associated with increas...
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COVID-19 Pandemic Causing Delays in Breast Cancer Care

 A high proportion of patients with breast cancer report significant delays in cancer care and treatment during the COVID-19 pandemic, according to the results of a patient survey now published in Breast Cancer Research and Treatment. As the pandemic continues to evolve, the majority of new cancer care guidelines have focused on minimizing the risk of spreading COVID-19 without compromising the outcomes of patients with cancer. However, because delays or interruptions in treatment can negat...
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