Delivering Immunotherapeutics Intratumorally: Safe for Treating Cancer?

Intravenous administration of chemotherapy is the conventional method of delivery. However, several issues arise with this method, including insufficient drug penetration into the tumor tissue. Intratumoral injections of immunotherapies directly into the tumor have been a possible solution to this problem, and, according to a recent study, results of which are published in JAMA Network Open, this technique has been found to be a viable option for a variety of histological conditions and target o...
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Emergency Departments’ Cancer Expertise Level Predicts Patient Outcomes

Cancer patients are frequent visitors of the emergency department for a myriad of cancer-related reasons, and several external factors can help predict patient outcomes. Researchers discovered that patients with cancer seeking emergency cancer-related treatment receive better outcomes when seen at a care facility with cancer expertise. In addition, they found that cancer expertise of an institution is more indicative of patient outcomes than continuity of care. In this study, published in Canadi...
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Nutrition Supplements: Do They Do More Harm Than Good?

According to a new study, nutrition supplements may not be as beneficial as nutrients derived from food for reducing all-cause mortality. In fact, certain supplements taken in excess may actually promote some cancers. "As potential benefits and harms of supplement use continue to be studied, some studies have found associations between excess nutrient intake and adverse outcomes, including increased risk of certain cancers," remarked Fang Fang Zhang, MD, PhD, Associate Professor at the Friedman ...
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Killing Leukemia Cells by Disrupting Amino Acid Consumption

Researchers at Winship Cancer Institute of Emory University found that inhibiting amino acid metabolism hinders leukemia cell growth. The investigators report that ASCT2, a transporter enzyme that carries amino acids into cells, is a potential therapeutic target for cancer. "So far, little progress has been made in finding therapeutic targets in amino acid metabolic pathways that can be harnessed to kill cancer cells but spare normal cells," remarked Cheng-Kui Qu, MD, PhD, Professor in the Depar...
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Immunotherapy Safe for Patients With HIV and Advanced Cancer

Patients infected with HIV are at increased risk of cancer. For example, Kaposi sarcoma is 500 times more likely to occur in patients with HIV than in the general population. Because of their compromised immune systems, patients with HIV are not able to partake in immunotherapy clinical trials. However, researchers at Georgetown University have now found that immunotherapy is quite successful in treating patients with HIV and advanced-stage cancers, producing side effects in only a slight percen...
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