How Genetic Testing Results Impact Breast Cancer Treatment: Allison Kurian, MD, MSc

​With our ever-growing understanding of mutations that increase cancer risk and the rise of targeted treatments such as poly (ADP-ribose) polymerase (PARP) inhibitors that are indicated for specific mutations, the use of germline genetic testing for patients with breast cancer has increased significantly in recent years. How are these test results affecting patients' treatment? In a population-based cohort study published recently published in JAMA Oncology, Allison W. Kurian, MD, MSc, and colle...
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The Effect of Germline Mutations on Breast Cancer Treatment

Patients with breast cancer for whom germline genetic testing reveals pathogenic mutations often receive treatment that deviates from standard therapeutic guidelines, according to results of a population-based cohort study published today in JAMA Oncology.The use and importance of germline genetic testing for patients with cancer has increased in recent years as our understanding has grown regarding mutations that increase cancer susceptibility and as targeted treatments such as poly ADP ribose ...
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B-Cell Acute Lymphoblastic Leukemia: New Subtypes Found

Although recent genetic research has identified a number of new subtypes of B-cell acute lymphoblastic leukemia (B-ALL), the genetic alterations that initiate many of these subtypes have until now been unknown. In a new study, published in Nature Genetics, researchers have created a revised taxonomy of B-ALL that incorporates 23 subtypes, including 8 new ones, as defined by chromosomal rearrangements, sequence mutations, or heterogeneous genomic alterations."B-ALL has remarkable molecular divers...
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Computer Model Predicts Course of Prostate Cancer

Understanding how a healthy cell turns into a malignant one has been a challenge for scientists. Researchers at Charité - Universitätsmedizin in Berlin may have come close to solving this enigma.In a study published in Cancer Cell, the researchers analyzed the tumor genomes of 300 prostate cancer patients by examining each molecular profile, sequencing encoded material within the cells' genetic substance, documenting chemical variations to the genetic code, and assessing the activity of specific...
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Healthy Stem Cells Have as Many Mutations as Leukemic Cells

Researchers have found that the quantity of genetic mutations of hematopoietic stem cells (HSCs) in patients with acute myeloid leukemia (AML) is no greater than that of healthy individuals. These mutations are largely generated by normal, age-dependent processes that are constantly active during everyone's life."We thought that people with leukemia would have more mutations than healthy people, but this is not the case," commented the study's principal investigator, Ruben Van Boxtel, PhD, of th...
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