Kaposi Sarcoma: Pomalidomide Granted Accelerated Approval

In the first new drug approval for Kaposi sarcoma in over 20 years, the FDA has expanded the indication for pomalidomide (Pomalyst®, Celgene) in an accelerated approval, both for HIV-negative patients with Kaposi sarcoma and for patients with AIDS-related Kaposi sarcoma resistant to highly active antiretroviral therapy (HAART).The approval was based on data from Study 12-C-0047 (NCT01495598), an open-label, single-arm phase 1/2 trial in which 28 patients with Kaposi sarcoma, including 18 who wer...
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How Does Cancer Treatment Affect Immune Health in HIV Patients?

In people with HIV and cancer, antiretroviral therapy is often used during cancer treatment to mitigate complications of HIV progression. However, questions regarding long-term effects of cancer treatment in this patient population remain, such as the immunosuppressive effects on HIV RNA level and CD4 count, which are indicators of a patient's morbidity and mortality. Therefore, scientists sought to measure the link between these biomarkers and associated mortality after cancer treatment. They p...
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Higher Cancer Mortality Rates in HIV-Positive Older Patients

According to researchers, the disparity in cancer mortality rates between older patients with both human immunodeficiency virus (HIV) and cancer and older patients who have cancer but not HIV is due to more than the suboptimal cancer treatment given to those with HIV.It has previously been established that patients with both HIV and cancer have higher rates of cancer-specific mortality in comparison to other patients with cancer, yet the cause of this discrepancy has not been fully explained."To...
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Immunotherapy Safe for Patients With HIV and Advanced Cancer

Patients infected with HIV are at increased risk of cancer. For example, Kaposi sarcoma is 500 times more likely to occur in patients with HIV than in the general population. Because of their compromised immune systems, patients with HIV are not able to partake in immunotherapy clinical trials. However, researchers at Georgetown University have now found that immunotherapy is quite successful in treating patients with HIV and advanced-stage cancers, producing side effects in only a slight percen...
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