Understanding Glioblastoma Tumor-Associated Macrophages

One of the significant contributors to glioblastoma, a cancer of the brain and one of the most aggressive malignancies, tumor-associated macrophages have great potential as therapeutic targets; however, targeting these cells has not been effective, in part due to a limited understanding of the reasons behind their behavior. Researchers seeking to better understand this behavior have now discovered that tumor-associated macrophages are composed of two cell types: brain-resident microglia and bone...
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Blocking Clever-1 Enables Macrophages to Fight Cancer

Researchers at the University of Turku in Finland discovered that an antibody therapy can "re-educate" macrophages to activate killer T cells to fight cancer. The investigators' results, found in mouse models, are now being validated in patients in a phase 1/2 clinical trial.Macrophages preserve stability in the immune system by acting as the first line of defense against pathogens and invaders. Cancerous cells are able to control macrophages in order to maintain their own growth, however, by in...
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Helping Macrophages Overcome Cancer’s “Don’t Eat Me” Signal

Macrophages are immune cells capable of engulfing and devouring foreign, harmful, or diseased particles, including tumor cells. As such, they are important to the immune system's fight against cancer. However, many tumors avoid macrophages' attack by expressing CD47, a protein found on the surface of many cells throughout the body that sends a signal telling the macrophages not to eat the cells in question. In a study published in Nature Immunology, researchers have found a way to help macrophag...
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