Trunk and Extremity Melanoma Debate: Similar Outcomes for Mohs Micrographic Surgery Versus Wide Local Excision

Survival outcomes did not change significantly for patients with melanoma of the trunk or extremity when treated with Mohs micrographic surgery (MMS) compared with wide local excision, according to the results of a retrospective cohort study published recently in JAMA Dermatology. The retrospective cohort study was designed because previous studies indicated differences in overall survival outcomes for patients with head and neck cancers. However, this study indicates that those results do not a...
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Venous Thromboembolism Recurrence in Patients With Cancer

In patients with cancer who develop venous thromboembolism (VTE), cancer type plays a significant role in the risk of VTE recurrence after anticoagulation. A condition involving the formation of a blood clot that starts in a vein, VTE can negatively impact the clinical outcomes of patients undergoing cancer treatment. While anticoagulation therapies, including apixaban and rivaroxaban, are mainstays of treatment, patients with cancer experience higher rates of anticoagulation failure and bleedin...
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Nadofaragene for High-Grade BCG-Unresponsive NMIBC

‚ÄčIntravesical nadofaragene firadenovec is an effective and well-tolerated treatment for high-grade nonmuscle invasive bladder cancer (NMIBC) carcinoma in situ (CIS) that does not respond to intravesical Bacillus Calmette-Guerin (BCG), according to results of a multicenter, open-label phase 3 trial presented this past Friday at the 2020 Genitourinary Cancers Symposium. For patients with BCG-unresponsive NMIBC, there is a substantial risk of disease recurrence and progression. Cystectomy is often ...
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Continued Induction, Maintenance, or Observation: Which Is Most Effective for Metastatic Colorectal Cancer?

For patients with metastatic colorectal cancer, the standard treatment is induction combination chemotherapy with a targeted agent. However, clinical trials that involved patients either continuing cytotoxic therapy until disease progression or observation have shown inconsistent efficacy results. To close this gap, a systematic review and network meta-analysis was conducted and revealed that continued induction therapy until progression offered no survival benefit compared with maintenance fluo...
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What Are the Most Common Causes of Death for Breast Cancer Survivors?

Researchers discovered that a significant number of breast cancer survivors die from heart and cerebrovascular diseases, providing important insight on how breast cancer survivors should be counseled on potential health risks. In this study, published in Cancer, data on 754,270 women who were diagnosed with breast cancer during 2000 through 2015 from the Surveillance, Epidemiology, and End Results (SEER) program were analyzed. The researchers then calculated standardized mortality ratios for cau...
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