Radiotherapy Dose Exposure Linked to Major Adverse Cardiac Events in NSCLC

In patients with locally advanced non-small cell lung cancer (NSCLC) treated with thoracic radiotherapy, a greater left anterior descending (LAD) coronary artery dose exposure was associated with an increased risk of major adverse cardiac events (MACE) and all-cause mortality, particularly in patients with baseline coronary heart disease (CHD), according to results of a cohort study now published in JAMA Oncology. "Development of cardiac adverse events is a well-recognized risk following radioth...
Continue reading

Breast Cancer: No Survival Benefit From IM-MS Irradiation

Fifteen-year results of a randomized phase 3 trial show that for patients with stage I–III breast cancer, internal mammary and medial supraclavicular (IM-MS) lymph node chain irradiation reduces breast cancer mortality and breast cancer recurrence but does not produce a significant improvement in overall survival. "Ten-year results from several studies showed improved disease-free survival and distant metastasis-free survival, reduced breast cancer-related mortality, and variable effects on over...
Continue reading

Transoral Robotic Surgery Improves Survival in Older Patients With HPV-Related Oropharyngeal Carcinoma

Transoral robotic surgery with pathologic characteristics-guided adjuvant therapy may improve survival outcomes in older patients with human papillomavirus (HPV)-related oropharyngeal carcinoma (OPSCC), according to a retrospective cohort analysis now published in JAMA Otolaryngology–Head & Neck Surgery. Because patients over 70 years of age are underrepresented in clinical trials for HPV-related oropharyngeal cancers, the optimal way to treat these patients remains controversial. Additional...
Continue reading

Murray Brunt, MBBS on 10-Year Results of FAST: 5-Fraction RT for Breast Cancer

Ten-year results from the FAST study show that there are no significant differences in normal tissue effects (NTE) rates after 28.5 Gy/5 fractions (fr) compared with 50 Gy/25 fr in patients with early breast cancer; however, NTE were higher with 30 Gy/5 fr, according to a study published in the Journal of Clinical Oncology. In an interview with i3 Health, Murray Brunt, MBBS, FRCP, FRCR, lead study author, provides insights on the significance of these results and how treatment will evolve in the...
Continue reading

How Does Cancer Treatment Affect Immune Health in HIV Patients?

In people with HIV and cancer, antiretroviral therapy is often used during cancer treatment to mitigate complications of HIV progression. However, questions regarding long-term effects of cancer treatment in this patient population remain, such as the immunosuppressive effects on HIV RNA level and CD4 count, which are indicators of a patient's morbidity and mortality. Therefore, scientists sought to measure the link between these biomarkers and associated mortality after cancer treatment. They p...
Continue reading

Copyright © 2021 Oncology Data Advisor. All rights reserved.