Tazemetostat for Follicular Lymphoma Granted Accelerated Approval

Tazemetostat (TAZVERIK™, Epizyme, Inc.) has been approved for adult patients with relapsed or refractory (R/R) follicular lymphoma (FL) who have tumors that are positive for an EZH2 mutation, have received at least 2 previous systemic therapies, and have no satisfactory alternative treatment options. In addition, the FDA approved the cobas® EZH2 Mutation Test (Roche Molecular Systems, Inc.) as a companion diagnostic for tazemetostat. An EZH2 inhibitor, tazemetostat has previously been approved f...
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Tazemetostat Approved for Epithelioid Sarcoma

The FDA has granted accelerated approval to tazemetostat (TazverikTM, Epizyme) for the treatment of adult and pediatric patients aged 16 or older with unresectable locally advanced or metastatic epithelioid sarcoma. Epithelioid sarcoma, which often occurs in young adults and comprises less than 1% of all soft tissue sarcomas, carries a high risk of local and regional spread, and it metastasizes in approximately 30% to 50% of cases. Tazemetostat, a first-in-class selective enhancer of zeste ...
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