Metronomic Capecitabine Maintenance for TNBC: Zhongyu Yuan, MD

Metronomic capecitabine maintenance therapy has been shown to be more effective compared with observation for patients with triple-negative breast cancer (TNBC), according to a study led by Zhongyu Yuan, MD. Results of the study have been presented at the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program. In this interview with i3 Health, Dr. Yuan shares insights on treating TNBC and future directions in the TNBC treatment landscape. What are the most challenging aspec...
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TNBC: Metronomic Capecitabine Maintenance Improves Outcomes

Metronomic capecitabine maintenance after standard treatment has been shown to be a successful therapy for patients with triple-negative breast cancer (TNBC) in a recent study. Results of this study will be reported on later this week in the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program. Relapse and unfavorable outcomes are still issues among patients with TNBC. According to lead study author XI Wang, MD of the Department of Breast Oncology at Sun Yat-Sen Universit...
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Sacituzumab Govitecan for TNBC: An Interview With Sara Tolaney, MD, MPH

The FDA recently granted approval to sacituzumab govitecan-hziy (Trodelvy™, Immunomedics, Inc) for patients with metastatic triple-negative breast cancer (TNBC) who have received at least two prior therapies. Approval was based on a clinical trial (NCT01631552) that enrolled 108 patients with metastatic TNBC. In an interview with i3 Health, Sara Tolaney, MD, MPH, one of the study authors, provides insights on treating TNBC and the significance of the sacituzumab govitecan approval. What are the ...
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FDA Grants Approval to Sacituzumab Govitecan-Hziy for TNBC

Accelerated approval was granted to sacituzumab govitecan-hziy (Trodelvy™, Immunomedics, Inc), a Trop-2-directed antibody and topoisomerase inhibitor drug conjugate, for patients with metastatic triple-negative breast cancer (TNBC) who have received at least two prior therapies. Sacituzumab govitecan-hziy works by targeting the Trop-2 receptor, mitigating cancer growth and spread. In addition, this drug is linked to topoisomerase inhibitor, which is a chemical compound toxic to cancer cells. "Me...
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Disparities Among Patients With Triple-Negative Breast Cancer

Historically, triple-negative breast cancer (TNBC), a disease that tests negative for estrogen, progesterone, and human epidermal growth factor receptors, is more aggressive and carries a worse prognosis than most other types of breast cancer. Researchers conducted a study to understand risk factors that cause disparities in diagnosis in order to develop preventive measures for TNBC and found that women of color and younger women are most at risk of developing TNBC. For this study, published in ...
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