John Leonard, MD: FDA Approval of Selinexor for DLBCL

Selinexor (Xpovio®, Karyopharm Therapeutics) was recently FDA approved to treat relapsed/refractory diffuse large B-cell lymphoma (DLBCL). This approval extends to patients with DLBCL that resulted from follicular lymphoma and those who had previously received at least two prior lines of systemic therapy. John Leonard, MD, the Richard T. Silver Distinguished Professor of Hematology and Medical Oncology at Weill Cornell Medicine, discussed with i3 Health the importance of this approval and the fu...
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Lenalidomide/Rituximab for Follicular Lymphoma and Marginal Zone Lymphoma: John P. Leonard, MD

This week, the FDA approved lenalidomide (Revlimid®, Celgene Corporation) in combination with a rituximab product for relapsed/refractory follicular lymphoma (FL) and relapsed/refractory marginal zone lymphoma (MZL). In this interview with i3 Health, John P. Leonard, MD, lead author of the AUGMENT trial, on which the approval was based, discusses the approval's importance and shares his advice for physicians treating patients with relapsed/refractory FL or MZL. Can you comment on the significanc...
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Lenalidomide Approved: Follicular Lymphoma and Marginal Zone Lymphoma

​The FDA has approved lenalidomide (Revlimid®, Celgene Corporation) in combination with a rituximab product for relapsed/refractory follicular lymphoma (FL) and relapsed/refractory marginal zone lymphoma (MZL). Follicular lymphoma is the most common form of indolent (slow growing) B-cell non-Hodgkin lymphoma (NHL), accounting for around 20% to 30% of all NHL cases. Marginal zone lymphoma, another type of indolent B-cell NHL, comprises approximately 8% of all NHLs. "Current treatment options for ...
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